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Lsy-6 microRNA
lsy-6 microRNA belongs to the class of miRNAs; these function to regulate the expression levels of other genes by several mechanisms. lsy-6 is a short non-coding RNA molecule and the first miRNA identified as having a role in nervous system development. It regulates left-right neuronal asymmetry in the nematode worm ''Caenorhabditis elegans''.
==Left-right asymmetry through the ''cog-1'' gene==
ASEL and ASER are a pair of bilateral taste receptor neurons thought to be responsible for the asymmetrical pattern of chemoreceptor gene expression in ''C. elegans''. These two gustatory neurons are bilaterally symmetric morphologically, as well as with regards to their connectivity, position and gene expression patterns. However, they are left-right asymmetric in their expression of specific signalling molecules. The ASE neuron is extremely sensitive to the correct dosage of ''cog-1'', an Nkx-type homeobox gene, and extra copies of this gene will readily produce left/right asymmetry defects.
lsy-6 is responsible for control of cog-1 expression, as transcriptional mechanisms alone are not sufficient for this regulation. lsy-6 and cog-1 are initially co-expressed by both ASEL and ASER after birth, but their expression later becomes restricted to one of the two ASE neurons (ASEL for lsy-6 and ASER for cog-1). lsy-6 codes for a 21-nt miRNA, which in turn binds to a single complementary site in the 3' UTR of the ''cog-1'' gene. This interaction is only seen in the ASEL cell type (not the ASER), thus causing an asymmetric cog-1 distribution. It has been observed that a removal of lsy-6 leads to an altered transcription of cog-1 in ASEL, indicating that despite expressing lsy-6, the ASEL neuron does not transcribe cog-1.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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